CHARACTERIZING THE CONSENSUS RESIDUE SPECIFICITY AND SURFACE OF BCL-2 BINDING TO BH3 LIGANDS USING THE KNOB-SOCKET MODEL

Cancer cells bypass cell death by changing radio birdman tshirt the expression of the BCL-2 family of proteins, which are apoptotic pathway regulators.Upregulation of pro-survival BCL-2 proteins or downregulation of cell death effectors BAX and BAK interferes with the initiation of the intrinsic apoptotic pathway.In normal cells, apoptosis can occu

This study focuses on the main urban area of Yangzhou City and conducts a quantitative comparative analysis of traffic accessibility during normal weather and extreme precipitation conditions (typhoon) based on GPS trajectories of buses.From both temporal and spatial dimensions, it comprehensively examines the impact of extreme precipitation on bus